CD11b immunophenotyping identifies inflammatory profiles in …
2015年9月30日 · In vivo targeting of CD11b pos lung macrophages. CD11b is ubiquitously expressed on monocytes and neutrophils, which prevents the exclusive targeting of AMΦs using anti-CD11b mAbs.
Alternations in inflammatory macrophage niche drive phenotypic …
2024年10月29日 · Remarkably, the population of CD11b low F4/80 high resident-like macrophages was diminished, whereas CD11b high F4/80 high bone marrow-derived macrophages became the dominant macrophage population ...
Integrin CD11b activation drives anti-tumor innate immunity
2018年12月19日 · Pharmacological activation of CD11b with a small molecule agonist, Leukadherin 1 (LA1), promotes pro-inflammatory macrophage polarization and suppresses tumor growth in animal models of murine...
Altered Membrane Expression and Function of CD11b Play a Role …
2023年2月13日 · Morphine at sub-nM to nM levels alone modulates macrophage CD11b function and reduces phagocytosis, while MOR is also expressed in macrophages, suggesting that morphine-mediated immunomodulation may be mediated through direct interaction with MOR on …
Crosstalk Between CD11b and Piezo1 Mediates Macrophage …
CD11b has previously been shown to play an important role in regulating macrophage inflammatory responses. Macrophages from CD11b deficient mice exhibit enhanced inflammation in response to LPS, suggesting that CD11b negatively regulates macrophage inflammatory activation . However, the role of this integrin in transducing mechanical stretch in ...
Critical role of CD11b+ macrophages and VEGF in inflammatory ...
2009年5月28日 · Depletion of macrophages including CD11b + /Gr-1 + macrophages markedly reduces LPS- or LTA-induced lymphangiogenesis in the skin. CDL (25 mg/kg, CD) was given intravenously to deplete macrophages at 1 day before and after the intradermal injection of LPS (LPS + CDL) or LTA (LTA + CDL).
Crosstalk Between CD11b and Piezo1 Mediates Macrophage
2021年9月22日 · Together, this study demonstrates that the physical environment synergizes with biochemical cues to regulate macrophage morphology and function, and suggests a role for CD11b and Piezo1 crosstalk in mechanotransduction in macrophages.
Three tissue resident macrophage subsets coexist across organs …
2022年1月7日 · By E19.5, the majority of Td + cells were CD11b + CD64 + macrophages (~80%; Fig. 5C). We assessed the fate of E14.5-labeled cells by gating on Td + macrophages and then stratifying them based on TIMD4 and CCR2 expression.
CD11b Marker for Macrophages and Microglia - Bio-Techne
CD11b is a protein on immune cells like macrophages and microglia, aiding in cell adhesion, migration, and immune response. It’s used in immune and neuro research.
Tissue-specific macrophages: how they develop and choreograph …
2023年3月15日 · Although tissue-resident macrophages can be identified by a combination of a few pan-macrophage markers in every tissue (for example, CD11b, F4/80, MERTK and CD64), each subtissular niche in ...