Autophagy: Regulator of cell death | Cell Death & Disease - Nature
2023年10月4日 · Autophagy is the process by which cells degrade and recycle proteins and organelles to maintain intracellular homeostasis. Generally, autophagy plays a protective role in...
Autophagy - Wikipedia
In the selective autophagy is the autophagy of organelles; mitophagy, [36] lipophagy, [37] pexophagy, [38] chlorophagy, [39] ribophagy [40] and others. Macroautophagy is the main pathway, used primarily to eradicate damaged cell organelles or unused proteins. [41]
Autophagy pathway: Cellular and molecular mechanisms
This review will define this process and the cellular pathways required, from the formation of the double membrane to the fusion with lysosomes in molecular terms, and in particular highlight the recent progress in our understanding of this complex process.
An Overview of the Molecular Mechanism of Autophagy
Autophagy is a highly conserved cellular degradation process in which portions of cytosol and organelles are sequestered into a double-membrane vesicle, an autophagosome, and delivered into a degradative organelle, the vacuole/lysosome, for breakdown and eventual recycling of the resulting macromolecules.
Lipids associated with autophagy: mechanisms and therapeutic …
2024年10月30日 · Hippman RS, Snead AM, Petros ZA, Korkmaz-Vaisys MA, Patel S, Sotelo D, et al. Discovery of a small-molecule modulator of the autophagy-lysosome pathway that targets lamin A/C and LAMP1, induces ...
Autophagy genes in biology and disease - Nature
2023年1月12日 · Autophagy (‘self-eating’) is a collection of processes by which cellular components such as proteins and organelles are delivered to the lysosome or vacuole for degradation. Two autophagy...
Teaching the basics of autophagy and mitophagy to redox …
Autophagy is a lysosomal mediated degradation activity providing an essential mechanism for recycling cellular constituents, and clearance of excess or damaged lipids, proteins and organelles. Autophagy involves more than 30 proteins and is regulated by nutrient availability, and various stress sensing signaling pathways.
Autophagy in Human Health and Disease | New England …
2013年2月14日 · This review discusses the cellular process of autophagy (“self-eating”), which plays key roles in normal development of the immune system and adaptation to stress, as well as in a wide range ...
Autophagy pathway: Cellular and molecular mechanisms
2017年12月31日 · The autophagy pathway starts at the birth of the phagophore and ends at death of the autophagosome. The cellular and molecular lifecycle of this pathway has occupied cell biologists since the late 1950s.
Diving into the Evolutionary History of HSC70-Linked Selective ...
Very recently, along with the emergence of new concepts in the field of autophagy, Sahu et al. evidenced that KFERQ domain-containing proteins can additionally be subjected to parallel degradation in late endosomes/multivesicular bodies (LE/MVB) through a pathway referred to as endosomal microautophagy (eMI) . This alternative process ...