Acetoacetic acid - Wikipedia
Acetoacetic acid (IUPAC name: 3-Oxobutanoic acid, also known as Acetonecarboxylic acid or Diacetic acid) is the organic compound with the formula CH 3 COCH 2 COOH. It is the simplest beta- keto acid, and like other members of this class, it is unstable.
Acetoacetate | C4H5O3- | CID 6971017 - PubChem
2024-10-26. Description. Acetoacetate is a 3-oxo monocarboxylic acid anion that is the conjugate base of acetoacetic acid, arising from deprotonation of the carboxy group. It has a role as a human metabolite. It is functionally related to a butyrate.
Acetoacetate: What is it, Why It's Important & The Benefits
2022年9月24日 · Acetoacetate is the first ketone body produced in the liver while keto dieting. It’s the precursor to beta-hydroxybutyrate (BHB), a vital energy source when you’re in ketosis. What is the function of acetoacetate?
17.3: Ketone Bodies - Biology LibreTexts
2024年5月13日 · Ketone bodies are the name given to two molecules, acetoacetate (a ketone) and D-β-hydroxybutyrate (its reduction product) that derive from the condensation of acetate in the form of acetyl-CoA. Their structures are shown in Figure \(\PageIndex{1}\).
What Is Acetoacetate? What You Need to Know - Perfect Keto
2024年10月23日 · Acetoacetate is the first ketone produced in the body during ketosis. It’s important because it’s the precursor to beta-hydroxybutyrate, which is a vital energy carrier when you’re in ketosis. Acetoacetate is completely safe, but it is commonly confused with ethyl acetoacetate, which has various health warnings.
What is Acetoacetic Acid? High and low values - Healthmatters
2019年5月6日 · Acetoacetic acid (= acetoacetate) is a weak Beta-keto acid produced from acetyl-CoA in the mitochondrial matrix of hepatocytes. When there is decreased availability of glucose or impaired glucose metabolism, such as in diabetes mellitus, the acetyl-CoA is diverted to produce more acetoacetate, from which acetone and beta-hydroxybutyrate are ...
Acetoacetate - an overview | ScienceDirect Topics
Acetoacetate is a compound used in a chemical system to determine trichothecene mycotoxins like deoxynivalenol (DON) and nivalenol (NIV) in food samples. It reacts with formaldehyde and ammonium to form fluorescent dihydropyridine derivatives in a two-step modified Hantzsch synthesis process.
Ketone bodies - Wikipedia
When two acetyl-CoA molecules lose their -CoAs (or coenzyme A groups), they can form a (covalent) dimer called acetoacetate. β-hydroxybutyrate is a reduced form of acetoacetate, in which the ketone group is converted into an alcohol (or hydroxyl) group (see illustration on the right). Both are 4-carbon molecules that can readily be converted ...
Acetoacetic acid | C4H6O3 | CID 96 - PubChem
Acetoacetic acid is a 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent. It has a role as a metabolite. It is a ketone body and a 3-oxo fatty acid. It is functionally related to a butyric acid. It is a conjugate acid of an acetoacetate. …
Acetoacetic Acid - an overview | ScienceDirect Topics
Acetoacetate (AcAc) was discovered in 1865 in the urine of patients suffering from catastrophic diabetes mellitus. The accumulation of β-hydroxybutyrate (β-OHB) in the urine during 2–3 days of fasting was recognized in 1887.
Ketoacidosis - StatPearls - NCBI Bookshelf
2023年8月8日 · Ketoacidosis is a metabolic state associated with pathologically high serum and urine concentrations of ketone bodies, namely acetone, acetoacetate, and beta-hydroxybutyrate.
6.9: Ketone Body Synthesis - Biology LibreTexts
2023年8月31日 · In ketone body synthesis, an acetyl-CoA is split off from HMG-CoA, yielding acetoacetate, a four carbon ketone body that is somewhat unstable, chemically. It will decarboxylate spontaneously to some extent to yield acetone.
Ketones and the Heart: Metabolic Principles and Therapeutic ...
2023年3月30日 · The ketone bodies acetoacetate (AcAc), D-ß-hydroxybutyrate (D-ßOHB), and L-ß-hydroxybutyrate (L-ßOHB), depicted in center, have pleiotropic effects that act directly on the heart and systemically.
Acetoacetic Acid - an overview | ScienceDirect Topics
The three endogenous ketone bodies, acetoacetic acid, (R)-3-hydroxybutyric acid, and acetone, are structurally simple compounds derived from acetyl-CoA (Table 1). Ketones as a whole are more acidic than the corresponding alkane owing to …
Ketone Bodies: Definition, Formation and Function - Biology …
2020年6月11日 · Ketone bodies, or simply ketones are substances produced by the liver during gluconeogenesis, a process which creates glucose in times of fasting and starvation. There are three ketone bodies produced by the liver. They are …
Acetoacetate Accelerates Muscle Regeneration and Ameliorates …
Acetoacetate (AA) is a ketone body and acts as a fuel to supply energy for cellular activity of various tissues. Here, we uncovered a novel function of AA in promoting muscle cell proliferation.
Acetoacetate protects macrophages from lactic acidosis …
2021年12月8日 · Here the authors show that macrophages, in order to remain functional in acidosis, reduce their mitochondrial mass by mitophagy and rely on autophagy for survival, with mitochondrial integrity ...
Acetoacetate: Reference Range, Interpretation, Collection and …
Acetoacetate, also termed acetoacetic acid, is a weak β-keto acid produced from acetyl-CoA in the mitochondrial matrix of hepatocytes. Acetyl-CoA is also a precursor of cholesterol and...
Acetoacetate: Definition, Testing, and Significance | FAQs and …
2023年4月2日 · Acetoacetate is a type of ketone body that is produced in the liver during periods of low glucose availability, such as during fasting or a low-carbohydrate diet. It is an important fuel source for the body, particularly for the brain and other organs during times of glucose scarcity.
Frontiers | Acetate Revisited: A Key Biomolecule at the Nexus of ...
2020年11月11日 · Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether derived from the diet or from fermentation in the colon, has been implicated in a range of health benefits.