AMPA receptor - Wikipedia
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate and predominantly Na + ion channel that mediates fast synaptic transmission in the central nervous system (CNS).
Glutamate Receptors - Neuroscience - NCBI Bookshelf
Several types of ionotropic glutamate receptors have been identified. Three of these are ligand-gated ion channels called NMDA receptors, AMPA receptors, and kainate receptors (Figure 7.11C).
AMPA Receptor - an overview | ScienceDirect Topics
AMPA receptors are ionophores that primarily allow the passage of sodium ions, but certain structural variants also enable them to pass calcium ions. These calcium-permeable AMPA receptors are thought to contribute to spinal facilitation in conjunction with NMDA receptors.
Regulatory mechanisms of AMPA receptors in synaptic plasticity
2007年2月1日 · AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) are the main transducers of rapid excitatory transmission in the mammalian...
Structural and Functional Architecture of AMPA-Type Glutamate Receptors …
AMPA-type glutamate receptors are major mediators of excitatory synaptic transmission and plasticity. In this Review, Greger et al. summarize latest insights into receptor architecture, their assembly, and functional association with auxiliary subunits.
Visualization of AMPA receptors in living human brain with ... - Nature
2020年1月20日 · A newly developed PET tracer allows visualization of AMPA receptors in the living human brain, providing a new tool to study their potential involvement in neurological or psychiatric disorders.
AMPA Receptor - an overview | ScienceDirect Topics
AMPA receptors are glutamate-gated ion channels, present in a wide range of neuron types and in glial cells. Their main role is to mediate fast excitatory synaptic transmission, and therefore, they are critical for normal brain function.
AMPA receptor structure and auxiliary subunits - PubMed
Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA-type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter glutamate.
Hippocampal AMPA receptor assemblies and mechanism of …
2021年5月12日 · One subfamily of ionotropic glutamate receptors—called AMPA receptors (AMPARs)—has particularly important roles in the glutamatergic synapses of the hippocampus 1. AMPARs are tetrameric...
Structure and mechanism of AMPA receptor - PubMed
Ionotropic glutamate receptors in vertebrates are composed of three major subtypes - AMPA, kainate, and NMDA receptors - and mediate the majority of fast excitatory neurotransmission at chemical synapses of the central nervous system. Among the three major families, native AMPA receptors function as complexes with a variety of auxiliary ...