Regulation of 3′ splice site selection after step 1 of splicing by ...
2023年3月3日 · Post–step 1 regulation of alternative 3′ss selection by C* proteins. To investigate the function of C* proteins in splicing, we analyzed the effects of siRNA-mediated knockdown …
12.6: Splicing of introns in pre‑mRNAs - Biology LibreTexts
2023年6月20日 · The GU is the 5' splice site (sometimes called the donor splice site) and the AG is the 3' splice site (or acceptor splice site). GU is invariant at the 5' splice site, and AG is …
Mechanisms for U2AF to define 3′ splice sites and regulate
2014年10月19日 · U2AF is known to affect 3′-splice-site selection. Here, Fu and colleagues use genome-wide analysis of U2AF-RNA interactions to define U2AF's key roles in gene …
Postcatalytic spliceosome structure reveals mechanism of 3′–splice site …
2017年11月16日 · Here we present the 3.7-angstrom cryo–electron microscopy structure of the yeast P-complex spliceosome immediately after exon ligation. The 3′–splice site AG …
[Key Words: 3' Splice site; pre-mgNA; branchpoint sequences; lariat formation] Received August 22, 1989; revised version accepted October 24, 1989. The sequences required for splicing in …
The upstream 5′ splice site remains associated to the ... - Nature
2021年7月27日 · The splicing reaction is governed by four main regulatory consensus sequences: the 5′ and the 3′ splice sites (5′SS and 3′SS, respectively), which are located at exon–intron …
Diverse regulation of 3′ splice site usage - PMC
2015年9月14日 · In recent years, an increasing number of novel regulatory elements have been found within or nearby the 3′SS in mammalian genes. The diverse elements recruit a …
Elucidation of the aberrant 3′ splice site selection by cancer ...
2020年9月21日 · The accurate exclusion of introns by RNA splicing is critical for the production of mature mRNA. U2AF1 binds specifically to the 3´ splice site, which includes an essential AG …
What’s Wrong in a Jump? Prediction and Validation of Splice Site ...
2024年9月1日 · Cassette alternative exon and the alternative 3’ or 5’ splice site are the most common in humans (30% and 25%, respectively), while intron retention is typical of …
The role of branchpoint‐3′ splice site spacing and interaction …
1997年2月15日 · A conserved 3′ splice site YAG is essential for the second step of pre‐mRNA splicing but no trans‐acting factor recognizing this sequence has been found. A direct, …
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