QRICH1 dictates the outcome of ER stress through ... - Science
2021年1月1日 · Cells dynamically respond to ER stress by inducing up-regulation of QRICH1, which modulates translation and transit of proteins through the ER-Golgi secretory pathway. Thus, QRICH1 acts as a regulator of a distinct transcriptional module that coordinates cellular stress responses to regulate protein synthesis and secretion under homeostatic and ...
QRICH1 Gene - GeneCards | QRIC1 Protein | QRIC1 Antibody
2024年10月2日 · QRICH1 (Glutamine Rich 1) is a Protein Coding gene. Diseases associated with QRICH1 include Ververi-Brady Syndrome and Alacrima, Achalasia, And Impaired Intellectual Development Syndrome. An important paralog of this gene is ZMYM4.
QRICH1 Dictates the Outcome of ER Stress through …
2021年1月1日 · We found that QRICH1 and the SRP-mediated pathway genes are upregulated under ER stress (Fig. 6A). We next sought to investigate whether cell type-specific translational activity is critical for cell viability in human organoids.
2021年8月31日 · We identified QRICH1 as a key effector of the PERK-eIF2a axis of the UPR. QRICH1 controlled a transcriptional program associated with translation and secretory networks that were specifically up-regulated in inflammatory pathologies. Thus, QRICH1 dictates cell fate in response to pathological ER stress.
QRICH1 dictates the outcome of ER stress through ... - PubMed
2021年1月1日 · We identified QRICH1 as a key effector of the PERK-eIF2α axis of the UPR. QRICH1 controlled a transcriptional program associated with translation and secretory networks that were specifically up-regulated in inflammatory pathologies. Thus, QRICH1 dictates cell fate in response to pathological ER stress.
Glutamine-rich protein 1 (QRICH1) locates on chromosome 3p21.31, containing 11 exons and encoding a protein of 776 amino acids. Loss-of-function variants of QRICH1 are associated with the...
Active polypeptide MDANP protect against necrotizing ... - Nature
2023年12月21日 · Endoplasmic reticulum (ER) stress plays a critical role in necrotizing enterocolitis (NEC) pathogenesis through the PERK-eIF2ɑ-QRICH1 axis. The present study aimed to explore the protective...
Exploring the role of endoplasmic reticulum stress in recurrent ...
2024年10月15日 · We identified five key ERS-associated genes (TMEM33, QRICH1, MBTPS2, ERN1, and BAK1) linked to immune-related mechanisms, with RT-qPCR results aligning with bioinformatics findings. Our research findings offer a fresh and comprehensive perspective on the ERS-related genes' pathways and interaction networks, offering significant insights for the ...
QRICH1 dictates the outcome of ER stress through transcriptional ...
2021年1月1日 · Among these stress pathways, the unfolded protein response can elicit two divergent outcomes: adaptation to endoplasmic reticulum (ER) stress or termination by programmed cell death. You et al....
QRICH1 suppresses pediatric T-cell acute lymphoblastic ... - Nature
2024年9月4日 · In our pediatric T-ALL cohort from different centers, a lower QRICH1 expression was found associated with a worse prognosis of pediatric T-ALL. Overexpression of QRICH1 significantly inhibited...