Hemoglobin - Wikipedia
The amino acid sequence of any polypeptide is translated from a segment of DNA, the corresponding gene. There is more than one hemoglobin gene. In humans, hemoglobin A (the main form of hemoglobin in adults) is coded by genes HBA1, HBA2, and HBB. [30]
HBB Gene - GeneCards | HBB Protein | HBB Antibody
2024年10月2日 · HBB (Hemoglobin Subunit Beta) is a Protein Coding gene. Diseases associated with HBB include Sickle Cell Disease and Beta-Thalassemia, Dominant Inclusion Body Type. Among its related pathways are Innate Immune System and Erythrocytes take up carbon dioxide and release oxygen.
Evolution of Hemoglobin and Its Genes - PMC - PubMed Central …
Hemoglobin gene expression is restricted to erythroid cells. The genes are expressed at extremely high levels late in erythroid differentiation, with balanced production of α-globin and β-globin. Paralogous globin genes are expressed at progressive developmental stages.
HBB gene - MedlinePlus
The HBB gene provides instructions for making a protein called beta-globin. Learn about this gene and related health conditions.
Hemoglobin subunit beta - Wikipedia
β-globin is encoded by the HBB gene on human chromosome 11. Mutations in the gene produce several variants of the proteins which are implicated with genetic disorders such as sickle-cell disease and beta thalassemia, as well as beneficial traits such as genetic resistance to malaria.
Hemoglobin variants including Hb C, Hb D, and Hb E - UpToDate
2024年5月13日 · This topic discusses genetic variants in globin genes. This includes especially common variants that produce hemoglobin (Hb) C, D, E, and others. An approach to Hb C genetic test results is presented separately.
3043 - Gene ResultHBB hemoglobin subunit beta [ (human)]
the genetic variations that can alter the expression and function of the HBB gene; Hemoglobin is expressed by hepatocytes and oxidative stress upregulates its expression.
HBB hemoglobin subunit beta [Homo sapiens (human)] - Gene
2024年11月3日 · The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains.
Hemoglobin Variants: Biochemical Properties and Clinical Correlates
Diseases affecting hemoglobin synthesis and function are extremely common worldwide. More than 1000 naturally occurring human hemoglobin variants with single amino acid substitutions throughout the molecule have been discovered, mainly through their ...
Evolution of hemoglobin and its genes - PubMed
2012年12月1日 · This article presents the multiple genes and gene families encoding human globins, summarizes major events in the evolution of the hemoglobin gene clusters, and discusses how these studies provide insights into regulation of globin genes.