Glucagon-like peptide-1 - Wikipedia
Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino-acid-long peptide hormone deriving from the tissue-specific posttranslational processing of the proglucagon peptide. It is produced and secreted by intestinal enteroendocrine L-cells and certain neurons within the nucleus of the solitary tract in the brainstem upon food consumption.
GLP-1 Agonists: What They Are, How They Work & Side Effects
2023年7月3日 · GLP-1 Agonists. GLP-1 agonists are medications that help lower blood sugar levels and promote weight loss. There are many different types. And they’re just one part of your treatment plan if you have Type 2 diabetes or obesity. Your healthcare provider can help you decide if they’re right for you.
Glucagon-Like Peptide-1 Receptor Agonists - StatPearls - NCBI Bookshelf
2024年2月29日 · Glucagon-like peptide-1 (GLP-1) agonists are a class of medications utilized to treat type 2 diabetes mellitus (T2DM) and obesity. As a class of medications, they are among several pharmacological options for these endocrine diseases.
Glucagon-like Peptide-1: Actions and Influence on Pancreatic …
Glucagon-like peptide-1 (GLP-1) is an important post-prandial stimulus of pancreatic insulin secretion and regulator of glucose homeostasis. GLP-1 is coded by the preproglucagon gene which is expressed in the gut, brain, and α-cells of the pancreas.
Glucagon-like peptide 1 (GLP-1) - PubMed
Biochemically modified for enhanced potency and sustained action, GLP-1 receptor agonists are successfully in clinical use for the treatment of type-2 diabetes, and several GLP-1-based pharmacotherapies are in clinical evaluation for the treatment of obesity.
Glucagon-like peptide-1 receptor: mechanisms and advances in …
2024年9月18日 · The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital component of the G protein-coupled receptor (GPCR) family and is found primarily on the surfaces of various cell...
GLP-1 receptor agonist - Wikipedia
Glucagon-like peptide-1 (GLP-1) receptor agonists, also known as GLP-1 analogs, GLP-1DAs or incretin mimetics, [1] are a class of anorectic drugs that reduce blood sugar and energy intake by activating the GLP-1 receptor.
Glucagon-like peptide 1 in health and disease - Nature
2018年5月4日 · In healthy individuals, the incretin hormone glucagon-like peptide 1 (GLP1) potentiates insulin release and suppresses glucagon secretion in response to the ingestion of nutrients. GLP1 also...
The structure and function of the glucagon-like peptide-1 receptor …
Glucagon-like peptide-1 (7-36)amide (GLP-1) is a 30-residue peptide hormone released from intestinal L cells following nutrient consumption. It potentiates the glucose-induced secretion of insulin from pancreatic beta cells, increases insulin ...
Metabolic Messengers: glucagon-like peptide 1 - Nature
2021年1月11日 · Glucagon like peptide-1 (GLP-1), a peptide hormone from the intestinal tract, plays a central role in the coordination of postprandial glucose homeostasis through actions on insulin...