siRNA，shRNA，dsRNA，miRNA间的区别 - 知乎 - 知乎专栏
2、 dsRNA：双链RNA（double-stranded RNA, dsRNA） 它是一种有互补链的RNA，与细胞中发现的DNA相似，dsRNA构成了一些病毒（双链RNA病毒）的 基因组 。 像病毒RNA或siRNA之类的双链RNA能够促发真核细胞中的RNA干扰，引起脊椎动物中的干扰素反应。
Double-stranded RNA - Wikipedia
Double-stranded RNA (dsRNA) is RNA with two complementary strands found in cells. It is similar to DNA but with the replacement of thymine by uracil and the adding of one oxygen atom. [1] Despite the structural similarities, much less is known about dsRNA. [2]
双链RNA（dsRNA）和单链RNA（ssRNA）的区别 - 知乎
2022年10月13日 · dsRNA和ssRNA之间的区别. 定义：dsRNA是指具有两条互补链的RNA分子，而ssRNA是指具有单链的RNA分子。 意义：此外，dsRNA 出现在双链 RNA 病毒中，而 ssRNA 出现在单链 RNA 病毒中。 转录：通常，依赖 RNA 的 RNA 聚合酶转录 dsRNA，而只有负向 RNA …
Cellular origins of dsRNA, their recognition and consequences
2021年11月23日 · In this Review, we summarize recent reports showing endogenous sources of dsRNA (self dsRNA) and cellular responses that result from activation of dsRNA sensors by these cell-derived dsRNA...
miRNA、siRNA、dsRNA与shRNA 表示什么意思？ - biomart.cn
2015年6月28日 · siRNA，shRNA，dsRNA，miRNA间的区别. RNA干扰（RNAi），即用20多个核苷酸组成的短的双链RNA（siRNA）代替传统反义核酸进行转录后基因沉默，已经迅速而广泛地应用到基因功能，基因表达调控机制研究等热门领域，并为基因治疗开辟了新的途径。
双链核糖核酸 - 百度百科
双链核糖核酸（双链RNA，dsRNA），是由两条互补链复性形成的RNA分子，可以被Dicer酶切割形成siRNA。 双链核糖核酸，在体内具有抑制癌细胞快速分裂的作用。
Double Stranded RNA - an overview | ScienceDirect Topics
Double-stranded (ds) RNA is the most representative viral component that activates immune cells and induce type I interferons (IFN-α/β), which possess potent anti-viral activity. The synthetic dsRNA, polyinosinic-polycytidylic acid (poly(I:C)), has similar activity as dsRNA.
Cellular origins of dsRNA, their recognition and consequences
Double-stranded RNA (dsRNA) is associated with most viral infections - it either constitutes the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral replication. Hence, nearly all organisms have the capability of recognizing dsRNA and mounting a …
The competitive landscape of the dsRNA world - Cell Press
2023年12月19日 · During the 1970s, scientists realized viral infection of mammalian cells generated viral double-stranded RNA (dsRNA) that inhibited protein synthesis 1, 2 and triggered the interferon (IFN) response. 3 Today we know that all viruses make dsRNA using mechanisms involving defective interfering particles, panhandle structures, and convergent ...
The response of mammalian cells to double-stranded RNA - PMC
Once cytoplasmic sensors detect dsRNA, a chain of events is activated promoting inhibition of protein synthesis, transcriptional induction of interferon and other cytokines, and ultimately, cell death. This response to viral dsRNA is a key component of the interferon (IFN) system, and constitutes the first line of defense to limit viral ...