Skeletal stem and progenitor cells in bone physiology, ageing …
2024年10月8日 · Skeletal stem and/or progenitor cells (SSPCs) have crucial roles in bone physiology by giving rise to osteoblasts, chondrocytes and adipocytes, regulating osteoclastogenesis and...
Identification of the metaphyseal skeletal stem cell building
2024年2月23日 · Here, we identify a metaphyseal SSC (mpSSC) population whose transcriptional landscape is distinct from other bone mesenchymal stromal cells (BMSCs). These mpSSCs are marked by Sstr2 or Pdgfrb + Kitl −, located just underneath the growth plate, and exclusively derived from hypertrophic chondrocytes (HCs).
Insights into skeletal stem cells | Bone Research - Nature
2022年10月19日 · We discuss the principles and approaches to identify bona fide SSCs, highlighting pioneering findings that plot the lineage atlas of SSCs. The roles of SSCs and progenitors in long bone,...
Skeletal stem cells: insights into maintaining and regenerating …
Skeletal stem cells (SSCs) generate the progenitors needed for growth, maintenance and repair of the skeleton. Historically, SSCs have been defined as bone marrow-derived cells with inconsistent characteristics.
The mechanism of bone repair: Stem cells in the periosteum …
2022年11月15日 · The process of bone repair is orchestrated by stem cells in bone, generally termed skeletal stem/progenitor cells (SSCs). These stem cells are mobilized from both the outer periosteum and the inner bone marrow in response to injury, differentiate into bone-making osteoblasts, and deposit mineralized matrix at the injury site.
Skeletal stem cells in bone development, homeostasis, and disease
2024年4月6日 · Tissue-resident stem cells are essential for development and repair, and in the skeleton, this function is fulfilled by recently identified skeletal stem cells (SSCs). However, recent work has identified that SSCs are not monolithic, with long bones, craniofacial sites, and the spine being formed by distinct stem cells.
Zfp260 choreographs the early stage osteo-lineage commitment …
2 天之前 · The process of bone regeneration following injury was intricately controlled and primarily driven by skeletal stem cells (SSCs) lineage cells 1.These SSCs, located within bone tissue, possessed ...
First 'blueprint' of human skeletal development offers new …
5 天之前 · The first 'blueprint' of human skeletal development reveals how the skeleton forms, shedding light on the process of arthritis, and highlighting cells involved in conditions that affect skull and ...
Skeletal stem cells: origins, definitions, and functions in bone ...
2022年12月8日 · Skeletal stem cells (SSCs) are tissue-specific stem cells that can self-renew and sit at the apex of their differentiation hierarchy, giving rise to mature skeletal cell types required for bone growth, maintenance, and repair. Dysfunction in SSCs is caused by stress conditions like ageing and inflam …
Bone marrow and periosteal skeletal stem/progenitor cells ... - Cell …
2022年10月21日 · Skeletal stem/progenitor cells (SSCs) that are capable of contributing to bone repair are present in the periosteum on the outside surface of bones (Duchamp de Lageneste et al., 2018; Debnath et al., 2018; Ortinau et al., 2019; Matthews et al., 2021; Zhang et al., 2005), as well as inside the bone marrow (Chan et al., 2015; Zhou et al., 2014; Ma...