Interspecies differences in gastrointestinal physiology affecting …
2022年1月1日 · This review summarizes the formulation-related interspecies differences between humans and laboratory animals (beagle dogs and cynomolgus monkeys) based on publications from the last two decades. The article focuses on the GI physiological parameters that can markedly affect the in vivo performance of solid dosage forms.
Comparison of minipig, dog, monkey and human drug metabolism …
2015年7月1日 · Monkey, minipig and dog are the candidates with sufficient background data available for use in toxicology. Therefore, these three species are compared with humans. The liver is the major site of the metabolism of xenobiotics, steroids, cholesterol and bile acids.
Species differences between mouse, rat, dog, monkey and human …
In this review the authors describe similarities and differences in this respect among the different species, including man. This may be helpful for drug researchers to choose the most relevant animal species in which the metabolism of a compound can be studied for extrapolating the results to humans.
Species differences in hepatic and intestinal metabolic activities …
We had previously reported the species differences in intestinal and hepatic metabolic activities of 43 cytochrome P450 (CYP) substrates between cynomolgus monkeys and humans. However, the species differences between humans and rats or dogs had not yet been determined using comparable data sets with sufficient number of compounds. 2.
Princeton study suggests that monkeys, like humans, may have …
2020年10月15日 · Researchers have found that monkeys known as macaques possess the vocal anatomy but not the brain circuitry to produce human speech. The findings suggest that human speech stems mainly from the unique evolution and construction of our brains, and is not linked to vocalization-related anatomical differences between humans and primates.
Cynomolgus Monkey as an Emerging Animal Model to Study …
2022年3月1日 · Recent protein quantification by liquid chromatography–tandem mass spectrometry has revealed interspecies differences in the absolute abundance of transporters of the liver, kidney, and other tissues in humans, cynomolgus monkeys, beagle dogs, and Sprague-Dawley rats (Li et al., 2009a; Li et al., 2009b; Qiu et al., 2013; Wang et al., 2015 ...
Comparison of Canine and Human Physiological Factors
2021年4月28日 · This review is a summary of factors affecting the drug pharmacokinetics (PK) of dogs versus humans. Identifying these interspecies differences can facilitate canine-human PK extrapolations while providing mechanistic insights into species-specific drug in vivo behavior.
Species differences between mouse, rat, dog, monkey and human …
2006年11月24日 · In vivo assessment of cyclosporine, midazolam, nifedipine, tacrolimus, and verapamil has been reported in various species including the human, and the monkey might be an appropriate animal model for evaluating small intestinal first …
A Comprehensive Atlas of Immunological Differences Between Humans…
2022年3月10日 · For example, Fialuridine (TGN1412, CD28 superagonist antibody) was initially evaluated in four animal models (mice, rats, dogs, and monkeys), but when administered to humans at just 1/500 th of the dose found to be safe in animals, it caused catastrophic organic failure due to differences in CD28 expression between species . It is also ...
A Phylogenomic Study of Human, Dog, and Mouse - PLOS
2007年1月5日 · The evolutionary relationship of dog (Canis familiaris, order Carnivora), mouse (Mus musculus, order Rodentia), and human (Homo sapiens, order Primates) was examined applying a wide variety of distance measures and using the opossum (Monodelphis domestica) as the outgroup because, as a marsupial, it is the closest relative to the eutherian ...