ICOS coreceptor signaling inactivates the transcription factor FOXO1 …
2015年2月17日 — We report that ICOS signaling inactivates the transcription factor FOXO1, and a Foxo1 genetic deletion allowed for generation of Tfh cells with reduced dependence on ICOS ligand. Conversely, enforced nuclear localization of FOXO1 inhibited Tfh cell development even though ICOS was overexpressed.
ICOS maintains the T follicular helper cell phenotype by down ...
ICOS represses Klf2 via Foxo1 and Klf2 acts as a repressor of Cxcr5 and activator of S1pr1, Ccr7, and Selplg. DISCUSSION. CD28 and ICOS are two structurally and functionally closely related T cell co-stimulators (Hutloff et al., 1999). In this study, we analyzed the contribution of both molecules to specific phases of TFH cell differentiation ...
Transcriptional regulation of Tfh dynamics and the formation of ...
2024年6月3日 — ICOS-mediated activation signals not only induce Bcl6 and c-Maf, transcription factors that positively regulate Tfh differentiation (discussed below) but also inhibit Foxo1, Blimp1, and T-bet...
Akt2 Regulates the Differentiation and Function of NKT17 Cells
2018年9月12日 — ICOS has been demonstrated to be critical for the differentiation of NKT17 cells and we found that ICOS mRNA and protein expression was reduced in Akt2 KO iNKT cells. As a consequence, phosphorylation of FoxO-1 was downregulated in Akt2 KO thymocytes but the sequestration of FoxO-1 in the nucleus of Akt2 KO iNKT cells was increased.
FOXO transcription factors throughout T cell biology
2012年8月24日 — FOXO1 regulates CD4 + T cell differentiation, including the development and function of regulatory T cells and T helper 1 cells. In CD8 + T cell differentiation, FOXO1 is...
ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 …
2015年2月17日 — We report that ICOS signaling inactivates the transcription factor FOXO1, and a Foxo1 genetic deletion allowed for generation of Tfh cells with reduced dependence on ICOS ligand.
ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 …
2015年2月17日 — Semantic Scholar extracted view of "ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation" by E. Stone et al.
Foxo transcription factors in T cell biology and tumor immunity
2018年6月1日 — Foxo proteins regulate many aspects of effector T cell differentiation and memory responses. Foxo1 and Foxo3 directly activate the expression of Eomes, thereby control effector versus memory functional fate by regulating T-bet and Eomes expression. Foxo1 also promotes memory T cell differentiation via its induction of Tcf-7.
Flow cytometry Generation of FOXO1-EGFP knock-in mice The FOXO1-EGFP knock-in mice were generated at Taconic. Briefly, the EGFP sequence was inserted between the codon coding for the last amino acid of FOXO1 and the termination codon in exon 2 of the Foxo1 gene which allows for translation of a FOXO1-EGFP fusion protein.
Tet2 coordinates with Foxo1 and Runx1 to balance T follicular …
2022年6月15日 — Foxo1 coordinates with Tet2 at Runx2 and Runx3 loci to mediate their demethylation and expression. In addition, Foxo1 promotes the expression of Icos. Runx2 and Runx3 repress key T FH genes, including Icos and Cd200, to limit T FH cell differentiation.