Interactions between dihydropyridine receptors and ryanodine receptors ...
2002年5月1日 · Molecular interactions between two Ca 2+ ion channel proteins, the dihydropyridine receptor (DHPR) and the ryanodine receptor (RyR), underlie the essential process of excitation–contraction (EC) coupling in skeletal and cardiac muscle.
Interactions between dihydropyridine receptors and ryanodine receptors ...
This evidence is derived from studies of excitation-contraction coupling in intact myocytes and from experiments in isolated systems where fragments of the dihydropyridine receptor can bind to the ryanodine receptors in sarcoplasmic reticulum …
The Ca2+ influx through the mammalian skeletal muscle dihydropyridine …
2017年9月7日 · This sudden increase in intracellular Ca 2+ concentration triggers Ca 2+-sensitive Ca 2+ release channels or ryanodine receptors (RyR) to open and release massive amounts of Ca 2+ ions from ...
The molecular architecture of dihydropyrindine receptor/L-type …
2015年2月10日 · Cui, Y. et al. A dihydropyridine receptor alpha1s loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine...
Reciprocal dihydropyridine and ryanodine receptor interactions …
2011年10月13日 · This review surveys recent electrophysiological studies that bear on this signalling, and the possible reciprocal interactions between the dihydropyridine (DHPRs) and ryanodine receptors (RyRs) that may be involved in this coupling process.
An updated view of the structural basis for dihydropyridine receptors ...
2024年3月3日 · This presentation reviews images of electron micrographs from various skeletal muscles identifying a consistent association of diydropyridine receptors (DHPR) tetrads with alternate ryanodine receptors.
Interaction between the dihydropyridine receptor Ca2+ channel …
2005年12月15日 · The mechanism that couples muscle membrane excitation to the cytosolic Ca 2+ increase, also known as excitation-contraction (EC) coupling, is made possible by the strict functional and structural relationship of the dihydropyridine receptor (DHPR) and ryanodine receptor type 1 (RyR1) .
Dihydropyridine-induced Ca2+ release from ryanodine-sensitive …
2000年6月6日 · Based on results obtained in this study, we propose that a preactivated state of the DHP receptor that can activate the ryanodine receptor is reached not only by depolarization but also by binding of dihydropyridines to the DHP receptor.
Bi-directional coupling between dihydropyridine receptors and ryanodine ...
2002年3月1日 · Bi-directional coupling between dihydropyridine receptors and ryanodine receptors
Regulation of Dihydropyridine and Ryanodine Receptor Gene …
1995年10月27日 · The dihydropyridine (DHP) and ryanodine (RY) receptors play a critical role in depolarization-induced calcium release in skeletal muscle, yet the factors which govern their expression remain unknown.