The cGAS–STING pathway as a therapeutic target in ... - Nature
2021年4月8日 — The cGAS–STING pathway drives innate immune activation in response to cytosolic DNA. This is important for immunity to bacteria and viruses, but aberrant cGAS–STING activity is also linked to ...
cGAS-STING 信号通路发现史（上） - 知乎专栏
在NF-κB激活的经典途径（the canonical NF-κB pathway）中，病毒以内吞方式进入宿主细胞，被内体膜上的TLR7/8（RNA）和TLR9（CpG DNA）识别后，通过招募MyD88，IRAK4，IRAK1，TRAF6，TRAF3等一系列接头分子，激活IKK激酶。
DNA sensing by the cGAS–STING pathway in health and disease
2019年7月29日 — In this Review, we focus on the current understanding of DNA sensing through the cGAS–STING pathway, describing how the cytoplasmic cGAS receptor is activated, how downstream signalling is...
cGAS–STING cytosolic DNA sensing pathway - Wikipedia
The cGAS – STING pathway acts to detect cytosolic DNA and induce an immune response. Upon binding DNA, the protein cyclic GMP-AMP Synthase (cGAS) triggers reaction of GTP and ATP to form cyclic GMP-AMP (cGAMP). cGAMP binds to Stimulator of Interferon Genes (STING) which triggers phosphorylation of IRF3 via TBK1.
Molecular mechanisms and cellular functions of cGAS–STING ... - Nature
2020年5月18日 — The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes (STING), detects pathogenic DNA...
Advances in cGAS-STING Signaling Pathway and Diseases
2022年2月3日 — The cyclic GMP–AMP synthase (cGAS) stimulator of interferon gene (STING) signaling pathway is a critical natural immune pathway in cells. Early studies revealed that it plays a crucial regulatory role in pathogen infection and tumor, and it is associated with various human autoimmune diseases.
The cGAS-STING pathway: The role of self-DNA sensing in …
The cGAS-STING pathway has emerged as the major pathway for DNA sensing and plays a fundamental role in microbial surveillance. The role of this pathway in antiviral immunity makes it highly attractive for antivirus therapy or vaccine adjuvants.
New frontiers in the cGAS-STING intracellular DNA-sensing pathway
2024年4月9日 — The cGAS-STING pathway detects intracellular DNA and activates a potent antiviral response. Dvorkin and colleagues summarize recent insights into cGAS-STING biology and its role in host defense, immunopathologies, and anti-tumor immunity.
Cancer cell-specific cGAS/STING Signaling pathway in the era of ...
2023年9月1日 — The cGAS/STING pathway detects DNA damage-induced micronuclei or cytoplasmic chromatin fragments and triggers a proinflammatory anticancer immune response through either cytotoxic activities or immune stimulation (Yum et al., 2020, Mackenzie et al., 2017, Harding et al., 2017, Motwani and Fitzgerald, 2017). cGAS-mediated micronuclei recognition ...
cGAS-STING, an important pathway in cancer immunotherapy
2020年6月22日 — Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, is an important novel role in the immune system. Multiple STING agonists were developed for cancer therapy study with great results achieved in pre-clinical work.