The term "alert and oriented" (AO) is a medical notation describing a person's level of consciousness and cognition (the ability to understand and learn through thought, experiences, and the senses).

Now, a sweeping study published October 9 in Immunity unveils a mechanistic link between the two. Scientists led by Mikael Simons of the German Center for Neurodegenerative Diseases in Munich report ...

After a week of build-up, The Beatles have released what's been billed as their "final song". Called Now And Then, it's been 45 years in the making - with the first bars written by John Lennon in ...

Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ...

The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a ...