They release chemicals in response to allergens, which cause common allergy symptoms like tissue swelling and inflammation.

Mast cells are an important part of the immune system and help keep you healthy by triggering the body's inflammatory response and stimulating the release of substances that destroy pathogens (harmful ...

Whether cells in the human body survive or die under stress depends, among other things, on their mitochondria. Scientists at the Faculty of Medicine at the University of Freiburg have now shown that ...

“We go on to show that in vitro, human mast cells secrete IL-17A in response to various stimuli ... to sites of inflammation, as well as the molecular mechanisms that lead to mast cell activation.

An allergic inflammatory response is a sequential interaction ... bound to its high-affinity receptor FcRI on the membrane of mast cells and basophils. This leads to crosslinking of the IgE ...

Innate immune responses are initiated by mast cells and macrophages ... flow allows an influx of white blood cells, which cause inflammation in response to the signals. This inflammation leads ...

The inflammatory response is a localised defence mechanism used by the body following a physical injury or infection. In response to injury and infection, specialised immune cells called mast ...

“The introduction of our first bispecific candidate for inflammatory diseases, CDX-622, builds on our leadership in mast cell biology,” said Anthony Marucci, Co-founder, President and Chief ...