Since the expansion, Evotec has significantly scaled up its activities to develop highly promising compounds from Bristol Myers Squibb's industry-leading library of cereblon E3 ligase modulators ...

These results suggest an overall enhancement in nutritional quality of leaf mustard plants. Furthermore, the application of 10 mg/kg Se significantly enhanced the activity of phenylalanine ...

ATP-柠檬酸裂解酶（ATP-citrate lyase, ACLY）是脂肪酸合成代谢途径的第一个关键酶，催化底物柠檬酸与CoA形成脂肪酸从头合成所需的二碳单位乙酰辅酶A。

Riley states. However, she acknowledges that they “have yet to identify the E3 ligase(s) responsible for ubiquitinating mutant RIT1. Our CRISPR screen results identified several candidate E3 ligases, ...

This manuscript reports on the crystal structures of two glycosaminoglycan (GAG) lyases from the PL35 family, along with in vitro enzyme activity assays and comprehensive structure-guided mutagenesis.

The C2-WW-HECT domain ubiquitin ligase Nedd4L regulates membrane sorting during endocytosis through the ubiquitination of cargo molecules such as the epithelial sodium channel (ENaC). Nedd4L is ...

From the Centers of Inflammation, Translational, and Clinical Lung Research (Y. Shao, Y. Sun, Y.L., F.S., C.D., C.J., K.X., X.J., X.Y.), Temple University, Lewis Katz ...

Posttranscriptional regulation of gene expression by RNA-binding proteins can enhance the speed and robustness of cell state transitions by controlling RNA stability, localization, or if, when, or ...