Purpose: The effects of extreme temperatures on drug delivery of two albuterol sulfate hydrofluoroalkane, metered-dose inhalers (MDIs) were evaluated.Methods. Three Proventil HFA and three ...

The propellant-leak rate of the test MDIs was compared with that of the controls (Figure 3). The leak rates for ... actuation for both MDIs is 108 µg of albuterol sulfate, which corresponds ...

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