WE have found that isonicotinic acid hydrazide, a widely used drug 1, is a potent inhibitor of the crosslinking of fibrin. This reaction constitutes the terminal step in normal blood coagulation ...

(114,116) After that, the acyl-hydrazide dissociates or gets further deacylated to the free hydrazide, but none of these species show as high potency, selectivity, or τ as the original DFMO.