Objective: Estrogen-related receptor γ (ERRγ) is a metabolic regulator with no identified physiological ligands. This study investigates whether calcium is an ERRγ ligand that mediates the effects of ...

LEMS is caused by antibodies against presynaptic voltage-gated calcium channels and is ... 50 years of age who have antibodies to the acetylcholine receptor. The second is myasthenia gravis ...

Recent studies have shown that pharmacologic weight loss with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and combination therapies is approaching magnitudes achieved with surgery. However, ...

Synaptic NMDARs (N-methyl-D-aspartate receptors) and AMPARs (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors), two major classes of glutamate-gated ion channels, are localized to ...

This microscopic patrolman essentially dictates how neurons respond to external cues. Experts have identified it as the calcium permeable (CP)-AMPA receptor – a subtype of AMPA receptors. A team of ...

details of the mode of action of acetylcholine (ACh) remain unknown. We have considered stereochemical attachment of ACh at its nicotinic and its muscarinic receptor sites, and compared these two ...

This adaptation was first studied in detail in the 20th century. Researchers discovered that the mongoose’s receptors had a slight structural difference compared to those of other mammals.

These regions comprised distinct calcium compartments, distinguished by variable participation in waves, timing, and sensitivity to an M1 muscarinic acetylcholine receptor antagonist. However, we ...

Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four ...

Atherosclerosis causes the smooth, elastic lining of the coronary arteries to become hard, stiff, and swollen because of plaque. These are deposits of calcium, fats, and abnormal inflammatory cells ...