SUVN-502, developed by Suven Life Sciences, is a selective antagonist of the 5-HT6 serotonin receptor that mediates transmission of nerve signals for functions such as cognition and memory. Blocking ...

Here, a "5x5" game is not to be confused with a "5-on-5" game in which each team has five players. Instead, a 5x5 game is when a player gets to five or more in the following five statistical ...

Welcome to TechRadar's Marvel Phase 5 hub. In this article, you'll find the latest news and rumors on Marvel Cinematic Universe (MCU)'s current phase, which is due to end in July 2025. It's ...

Many of the neuropeptide receptors expressed centrally are also expressed peripherally and thus actions of agonists or antagonists of these receptors cannot be assumed to induce weight loss by ...

• Both receptors are essential for normal brain development and maintenance • Loss of LXR function leads to age-related neurodegeneration in multiple brain regions ...

The key role of the 5-HT 1A receptor in regulating aggression and impulsivity suggests that these behaviors and agitation in Alzheimer’s dementia may be mediated in part by altered activation of these ...

Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland ...

Although adjunctive SGAs treatment for the acute treatment of MDD is an advanced treatment option, there are a number of issues to be resolved: proper time to intervention, optimal patient ...

We used light-sensitive drugs to identify the brain region-specific role of mGlu5 metabotropic glutamate receptors in the control of pain. Optical activation of systemic JF-NP-26, a caged, normally ...

Here, we show that TGF-β-induced SMAD1/5 phosphorylation requires members of two classes of type I receptor, TGFBR1 and ACVR1, and establish a new paradigm for receptor activation where TGFBR1 ...