The efficacy and tolerability of zofenopril in the treatment of essential hypertension have been evaluated in four well-designed trials. In a dose-finding study (zofenopril 7.5 to 60 mg/day ...

Zofenopril is a prodrug that, once absorbed, undergoes rapid and complete hydrolysis to the sulfhydryl-containing active metabolite zofenoprilat. In healthy volunteers, a single oral dose of ...