Physiological extracellular matrix (ECM) calcification or mineralization is restricted to bones, teeth and the hypertrophic zone of growth plate cartilage. In contrast, pathological ECM ...

The extracellular matrix protein fibronectin forms fibrils when in association with cells that exert tension. Cells apply enough force to stretch fibrils in vivo. Stretching of individual ...

Our group has explored the regeneration of soft biological tissues through cell-extracellular matrix interactions, with a focus on collagen-rich environments and fibrosis. We have developed a new ...

Published in Science Advances, the study reveals how cells respond to the mechanical properties of the extracellular matrix, ...

In addition to HSPG binding, HB-GAM has similar carbohydrate binding sites in chondroitin sulfate proteoglycans (CSPGs). CSPGs are major inhibitory regulators of plasticity and regeneration in the CNS ...

What's really happening in the space between the cells in your body? With the Collagen Canvas project, students from Leiden ...

By analyzing proteomes and transcriptomes across tissues like the brain, heart, and skin, they uncovered proteins linked to ...

Tech millionaire Bryan Johnson, known for his anti-aging endeavors, experienced a setback during his "Project Baby Face" ...

A study at MedUni Vienna's Department of Dermatology provides insights into the diversity of cancer-associated fibroblasts in ...

A study provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory roles in the tumor environment. The results ...