Figure 3. Butyrate ameliorates bone loss. OC and autoantibodies both contribute to bone erosion. Butyrate mitigates bone erosion by inhibiting TNF-α and the RANKL downstream factors TRAF6 and NFATc1, ...

The NLRP3 inflammasome is activated by various danger signals ... MyD88, myeloid differentiation primary response 88; IRAK4, IL-1 receptor-associated kinase-4; TRAF6, tumor necrosis factor receptor- ...

Ventus Therapeutics US Inc. has divulged NLRP3 inflammasome inhibitors reported to be useful for the treatment of cancer, metabolic diseases, autoimmune diseases, and liver, renal, respiratory, ...

The term alert and oriented (AO) is a medical notation describing a person's level of consciousness and cognition (the ability to understand and learn through thought, experiences, and the senses). It ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...

Furthermore, Meyers et al provide evidence that PDK maintains NLRP3 inflammasome activation in murine and human macrophages as PDK inhibition reduces NLRP3 inflammasome-mediated inflammation and cell ...

Michael Boyle is an experienced financial professional with more than 10 years working with financial planning, derivatives, equities, fixed income, project management, and analytics. Suzanne is a ...

Department of Gynecological Oncology, Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P.R. China. *Corresponding Author: ...

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