Oncology Medicinal Chemistry, Pfizer Worldwide Research and Development, 10770 Science Center Drive, La Jolla, California 92121, United States ...

AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central ...

Co. Ltd. has patented new tricyclic compounds acting as serine/threonine-protein kinase ATR inhibitors and thus reported to be useful for the treatment of colon cancer.

University of Eastern Finland, Kuopio, Finland. Tousled-like kinase 2 (TLK2) is a ubiquitously expressed, nuclear serine/threonine kinase. The kinase activity of TLK2 and its closest human ...

No writing assistance was utilized in the production of this manuscript. BRAF, a member of a serine/threonine kinase protein family, serves as an immediate downstream effector of RAS in the MAPK ...

uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...

In a report released today, Silvan Tuerkcan from JMP Securities maintained a Buy rating on Acrivon Therapeutics, Inc. (ACRV – Research ...

In a report released today, Soumit Roy from JonesTrading maintained a Buy rating on Acrivon Therapeutics, Inc. (ACRV – Research Report), ...

RIPK1 – or receptor-interacting serine/threonine-protein kinase 1 – is thought to play a role in regulating the immune system, and has been a target for programmes both in inflammatory ...

§ p = 0.0001 between temsirolimus and IFN-α. ¶ p = 0.0001. # p = 0.0001. ** p = 0.001. NR: Not reported; ORR: Overall response rate; OS: Overall survival; PFS ...

Subsequent downstream analysis identified IGFBP3, ABCC6, ULK3, DOT1L, KLB, and AMH as promising candidates for drug repurposing. ULK3 is a serine/threonine protein kinase that functions as a pivotal ...