This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The ...

Hugo Snippert (UMC Utrecht, The Netherlands), and inserted by In-Fusion HD Cloning Plus (Takarabio) into a lentiviral vector including cPPT/CTS, WPRE, an EF1a promoter and IRES-puromycin-resistance ...

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore Joint School of the National University of Singapore and ...

Molecular mechanisms of therapy-induced tumor cell plasticity and associated resistance are largely unknown. Using a genome-wide CRISPR-Cas9 screen, we investigated escape mechanisms of NOTCH-driven ...

This previously unknown mechanism is essential for MRSA resistance. By understanding the details of this process, researchers are working towards developing inhibitors that can target MRSA's novel ...

Panelist discusses how an early analysis of the mechanisms of acquired resistance to first-line treatment with amivantamab plus lazertinib vs osimertinib was presented at the European Society for ...

Langmuir identified CO oxidation (gaseous CO colliding with O* atoms) over Pt catalyst as an example of a reaction occurring via this mechanism. (3) Noting the differences between gas-phase, ...

Ancient civilizations pioneered early versions of contemporary mechanisms, offering valuable insights into the origins of modern technology. An astrolabe. Credit: Anders Sandberg / Flickr / CC-BY-2.0 ...