In the future, a scale may be developed whereby HDX reactivity is predictive of the degree of structural flexibility and bias (propensity to form 2° structural elements such as α-helix, β-sheet, and β ...

Differentially expressed circFKBP8(5S,6) is a circular RNA with coding potential identified in control volunteers and patients with major depressive disorder (MDD). cFKBP8 is the protein encoded ...

According to TikTok’s Community Guidelines, the company does not allow showing or promoting disordered eating and dangerous weight loss behaviors. Content that falls in a gray area — like ...

Regions in protein sequences that are intrinsically disordered are known to play an important role in condensate formation. These regions have been extensively studied, but precisely how they ...

Zhang’s team examined the molecular machine responsible for making this type of modification to the mRNA. They found that the protein Serrate interacts with this molecular machine to keep a disordered ...

A study now identifies, for the first time, hundreds of brain proteins that explain inter-individual differences in functional connectivity and structural covariation in the human brain.

In this useful study, a solid machine learning approach based on a broad set of systems to predict the R2 relaxation rates of residues in intrinsically disordered proteins (IDPs) is described. The ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Modulating the function of Intrinsically Disordered Proteins (IDPs) with small ...

These microreactors can also selectively recruit phosphorylated proteins, providing insights into the evolution of enzymatic activity. The properties of biomolecular condensates can be regulated ...

Our observations reveal similarities between P granules and stress granules and identify intrinsically-disordered proteins as drivers of RNA condensation during P granule assembly. In this study, we ...