Altered SMO protein expression in human breast cancer was generally consistent with the Q-PCR results of Mukherjee et al. (Mukherjee et al. 2006) that showed increased mRNA expression in ~40 percent ...

1). Tumors can result from inactivating mutations in patched 1 or through activating mutations in SMO, which lies downstream. Figure 1: The Sonic hedgehog (Shh) signaling cascade is important in ...