The most advanced is NI-0101, which interferes with the dimerization of TLR4 by binding to an epitope on TLR4. 1A6 is an antibody that recognizes TLR4–MD-2 and when it was administered to a ...

Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi’an 710127, China Biotech. & ...

Furthermore, upregulation of HMGB1 is associated not only with neuroinflammatory markers such as IL-6 and ... This relationship is primarily reflected in their competitive binding to DNA interaction ...

When cardiomyocytes are exposed to LAD ligation (LADL) or OGD/R treatment, the TLR4/NF-κB pathway is activated, which increases the expression of NLRP3, pro-IL-18, and pro-IL-1β. Subsequently, NEK7 ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...

The significant increase of anti-inflammatory IL-10 with no significant increase in pro-inflammatory IL-1β and TNF-α confirms TLR4 binding unique to Gemini, and is further evidence of the ...

The significant increase of anti-inflammatory IL-10 with no significant increase in pro-inflammatory IL-1ß and TNF-a confirms TLR4 binding unique to Gemini, and is further evidence of the ...

The binding of lipids by allergens can favor Th2 immune responses by activation of the innate immune system. Activation of innate immune responses by allergens through triggering pattern ...

Inhibition of melanogenesis by 3-(1'-methyltetrahydropyridinyl)-2,4-6-trihydroxy acetophenone via suppressing the activity of cAMP response element-binding protein (CREB) and nuclear exclusion of ...

We reveal RNF41 is a negative regulator of Clec9A and the cross-presentation of dead cell-derived antigens by mouse dendritic cells. Intriguingly, RNF41 regulates the downstream fate of Clec9A by ...