NEC患儿肠道中的TLR4导致细胞释放出另外一种蛋白质HMGB1。该团队通过基因工程让小鼠体内缺乏HMGB1，然后让其患上NEC。这些小鼠大脑中小胶质细胞 ...

Based on neurite outgrowth assays, we have previously isolated, cloned, and produced as recombinant proteins two ligands of heparan sulfate proteoglycans (HSPGs), HMGB1 (high-mobility group B1; ...

The significant increase of anti-inflammatory IL-10 with no significant increase in pro-inflammatory IL-1β and TNF-α confirms TLR4 binding unique to Gemini, and is further evidence of the ...

The significant increase of anti-inflammatory IL-10 with no significant increase in pro-inflammatory IL-1ß and TNF-a confirms TLR4 binding unique to Gemini, and is further evidence of the ...

Subsequently, cytoplasmic additives are engulfed into autophagosomes and brought to the lysosomes for binding and degradation. Microautophagy is characterized by the autonomous modification of the ...

The binding of lipids by allergens can favor Th2 immune responses by activation of the innate immune system. Activation of innate immune responses by allergens through triggering pattern ...

Inhibition of melanogenesis by 3-(1'-methyltetrahydropyridinyl)-2,4-6-trihydroxy acetophenone via suppressing the activity of cAMP response element-binding protein (CREB) and nuclear exclusion of ...