Conclusion: Our results indicate that increased glycogen accumulation is primarily mediated through the gluconeogenesis pathway and that glycogen utilization is required for both migration and ECM ...

The role of the kidney in blood glucose-level regulation was until recently underestimated. Renal gluconeogenesis, renal glucose uptake and tubular glucose reabsorption are the three ways of renal ...

A research team has unveiled an adrenal independent pathway, the hypothalamus-sympathetic-liver (HSL) axis, to mediate stress ...

A team led by Researcher LIU Ji from the University of Science and Technology of China (USTC) of the Chinese Academy of ...

Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to ...

The projections estimate that 439 million people will be diabetic in 2030. T2DM is characterized by an impaired β-pancreatic cell function and insulin secretion, hyperglycemia and insulin resistance, ...

Hypoglycemia is an extremely common side effect of insulin therapy experienced mainly by patients with type 1 diabetes ...

Both insulin-dependent and insulin-independent processes contribute to fasting and postprandial plasma glucose regulation (Table ... glucose (glycogenolysis and gluconeogenesis), stimulates ...

Hepatocytes and, to a lesser extent, kidney cells can also use non-carbohydrate substrates, such as pyruvate, lactate, glycerol and glucogenic amino acids, to generate glucose-6-phosphate (G6P) in a ...