Researchers describe a method for evolving G protein–coupled receptors (GPCRs) with greater stability and enhanced expression. Sixty percent of all drugs target the class of membrane proteins ...
While this has been well established, the dimerization of G-protein coupled receptors (GPCRs) (that represents ∼1% of the genes present in a mammalian genome) has not been well documented until ...
G protein-coupled receptors (GPCRs) are the largest group of membrane proteins. GPCRs' primary function is to convert a wide range of extracellular stimuli, including biogenic amines, peptides ...
A mere six months ago Verily launched the study with Sosei Heptares – a global leader in GPCR structure-based drug design – with an aim to “prioritise protein targets for therapeutic ...
The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...