Classically, the GPCR signaling pathway is considered to be a three-component system that involves a seven-transmembrane-domain receptor, a trimeric G-protein complex (Gα, Gβ, Gγ) and an effector.
Surprisingly, however, depletion of all three eIF3 subunits increased MAPK/ERK pathway activity. Depletion of eIF3e and partially eIF3d also increased translation of TOP mRNAs that encode mainly ...
(A) The MAPK/ERK pathway activation by growth factors and receptor tyrosine kinases (RTKs). RTKs signal through GRB2-Sos and Ras to activate Raf-MEK-ERK signaling cascade. Active ERK phosphorylates ...
When the electrical signal reaches the end of one nerve cell ... It has been known for a long time that opioids release molecules called G proteins, which directly bind to calcium channels and ...
One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...