Its synthesis, which occurs in the mitochondria, through oxidative phosphorylation (OXPHOS ... self-assembly and enriched them with OXPHOS components to create SAOs capable of synthesizing ...

Our goal is to identify a therapeutic vulnerability within fatty acid synthesis or oxidation that can be leveraged to treat residual TNBC. Our lab’s prior studies demonstrate that chemoresistant ...

McGowan Institute for Regenerative Medicine, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States ...

We showed in Drosophila that spaced training triggers LTM formation by extending over several hours an increased mitochondrial metabolic activity in neurons of the ... The interplay between the two ...

Taken together, the present studies do not support a direct biochemical interaction between α-syn and LRRK2, or direct phosphorylation ... trafficking defects. Mitochondria: α-syn-positive ...