This important study shows that a splice variant of the kainate receptor Glu1-1a that inserts 15 amino acids in the extracellular N-terminal region substantially changes the channel's desensitization ...

On September 12 th, Bright Minds Biosciences announced the initiation of the BREAKTHROUGH Study, an open-label Phase 2 clinical trial evaluating the safety, tolerability, and efficacy of BMB-101 in ...

Kainate receptors play various important roles in synaptic transmission ... The data also shows that the insertion changes the modulatory effects of Neto proteins, resulting in altered rates of ...

“For example,” they wrote, “chronic exposure to THC has been reported to lead to the desensitization and downregulation of CB1 receptors, which may result in reduced CB1 agonist activity and therefore ...

with no evidence of receptor desensitization TRV045 demonstrates statistically significant, dose-dependent increase in measures of seizure threshold and shows seizure protection in validated ...

A team of Rice bioengineers has developed a mathematical model that clarifies why interleukin-12 ⎯ a potent immune-boosting protein that holds promise for cancer treatment ⎯ loses effectiveness over ...