Summary. Doripenem, a member of the β-lactam class of antibiotics, is the newest addition to the carbapenems. It exhibits concentration-independent bactericidal activity against gram-positive ...

a All were multicenter, multinational, randomized trials. ITT = intention to treat, VAP = ventilator-associated pneumonia, cIAI = complicated intraabdominal infection, NR = not reported or not ...

The emergence of multi-drug resistance in bacterial pathogens poses a threat to human health. Carbapenem-resistant microorganisms, especially Acinetobacter baumannii, has emerged as a serious ...

For Big Pharma, recent headlines out of China suggest multinational drugmakers are facing their share of challenges in the ...

Zai Lab ("Zai Lab", NASDAQ: ZLAB; HKEX: 9688) and Pfizer ("Pfizer", NYSE: PFE) announced today a strategic collaboration for ...

Broad-spectrum antibiotics, such as third-generation cephalosporins, quinolones and carbapenems, are categorized as “Watch” antibiotics that should be used with caution because of their high ...

Tebipenem is the first oral drug in the carbapenem antibiotic class to reach late-stage development and, despite the desperate need for new antimicrobials, was turned down in June by the FDA ...

further increases the threat of antibiotic resistance, according to a GlobalData analyst. The FDA delivered a blow to Spero's hopes of bringing the carbapenem to market in a complete response ...

Globally, Acinetobacter baumannii was among the top six leading pathogens for deaths associated with resistance in 2019, and CRAB is included in the highest priority category, the Critical Group ...

According to recent surveillance data from China 8, resistance of Acinetobacter baumannii to the carbapenem class of antibiotics has reached approximately 74%," said Josh Smiley, President and ...