Introduction Recent controlled trials have assessed the efficacy of phospodiesterase-5 (PDE-5) inhibitors in secondary Raynaud's phenomenon (RP). However, the conclusions are conflicting, and whether ...

For example, nimesulide is a weak competitive inhibitor of COX-1 but a potent time-dependent inhibitor of COX-2, whereas celecoxib exhibits slow competitive binding and, at higher concentrations ...

Boehringer Ingelheim has moved one of its top pipeline prospects – oral phosphodiesterase 4B (PDE4B) inhibitor BI 1015550 – into late-stage clinical testing for idiopathic pulmonary fibrosis ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01524. Molecular formula strings and the associated ...

Skip More from 5 Live... The 5 Live at 30 Yearbook How 5 Live reported on some of the biggest news and sport stories of the past 30 years. Eleanor Oldroyd: 30 years of "my radio family" Eleanor ...

Live rugby union commentary of Scotland v Portugal in the Autumn Internationals.

py-pde is a Python package for solving partial differential equations (PDEs). The package provides classes for grids on which scalar and tensor fields can be defined. The associated differential ...

If no political party is willing to say uncle, the drawn-out stalemate in the House of Commons is heading for an unprecedented situation that could amount to a tacit lack of confidence in the ...