A paper published in Cell reveals that the PfSUB1 subtilisin-like serine protease is required for the exit of merozoites from infected erythrocytes. This enzyme is sequestered in exonemes ...
It blocks mannan-binding lectin-associated serine protease-3 (MASP-3), the key activator of the alternative pathway, stopping the conversion of pro-complement factor D (pro-CFD) to mature CFD.