In one pathway, mTOR assembles with its RAPTOR subunit to form mTOR Complex 1 (mTORC1), while in the other pathway RAPTOR is replaced by RICTOR to form mTORC2. mTORC1 activation requires nutrients, ...

The drug blocks the activity of a protein known as mammalian target of rapamycin (mTOR), which promotes proliferation through the activation of proteins such as S6 kinase. Although the mTOR ...