Physiological extracellular matrix (ECM) calcification or mineralization is restricted to bones, teeth and the hypertrophic zone of growth plate cartilage. In contrast, pathological ECM ...

Our group has explored the regeneration of soft biological tissues through cell-extracellular matrix interactions, with a focus on collagen-rich environments and fibrosis. We have developed a new ...

The extracellular matrix protein fibronectin forms fibrils when in association with cells that exert tension. Cells apply enough force to stretch fibrils in vivo. Stretching of individual ...

Cancer-associated fibroblast subtypes modulate the tumor immune microenvironment and are associated with the aggressiveness ...

Published in Science Advances, the study reveals how cells respond to the mechanical properties of the extracellular matrix, ...

By analyzing proteomes and transcriptomes across tissues like the brain, heart, and skin, they uncovered proteins linked to ...

In addition to HSPG binding, HB-GAM has similar carbohydrate binding sites in chondroitin sulfate proteoglycans (CSPGs). CSPGs are major inhibitory regulators of plasticity and regeneration in the CNS ...

A study at MedUni Vienna's Department of Dermatology provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory ...

Accumulation of extracellular matrix (ECM) in liver fibrosis is associated with changes in protein abundance and composition depending upon etiology of the underlying liver disease. Current efforts to ...