and T cell receptors (TCRs) in jawed vertebrates, the variable lymphocyte receptors (VLRs) of jawless vertebrates are composed of variable LRR sequences linked by a flexible invariant stalk region ...

Jawless fishes, the 'sister' group of jawed vertebrates, use leucine-rich repeat–containing proteins as antigen receptors. New work shows that the two isotypes of variable lymphocyte receptors ...