Clinical observations of patients with Nasu–Hakola disease and molecular studies on the TREM2–TYROBP pathway might offer interesting insights into microglial physiology and the involvement of ...

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Both in a cultured microglial cell line and in human iPSC-derived microglia, the scientists sparked intracellular aggregates by treating the cells with recombinant ApoE and fluorescently labeled Aβ42 ...

They found that female, but not male, mice with both APOE4 and TREM2 R47H exhibited significant ... brains to the brain's immune cells, called microglia. Normally, microglia protect the brain ...

TREM2, a receptor predominantly expressed in microglia, regulates microglial proliferation, survival, migration, and phagocytosis, including clearance of amyloid plaques (one of the hallmarks of ...

While its counterpart, TREM2, had been linked to Alzheimer's ... "There is a broad consensus that microglia, the resident macrophages of the brain, are critical in maintaining brain health ...

Vigil Neuroscience routinely posts information that may be important to investors in the “Investors” section of its website at https://www.vigilneuro.com. The company encourages investors and ...

Large genome-wide association studies have implicated glia in AD pathogenesis, with most risk genes (APOE, TREM2, CD33, ABI3, PLCG2 etc.) being expressed predominantly in microglia and / or astrocytes ...

“We believe that increased TREM2 signaling via AL002 may recruit disease-fighting microglia to broadly counteract the progression of Alzheimer’s disease. INVOKE-2 is designed to provide meanin ...

Data from INVOKE-2, evaluating TREM2 agonist candidate AL002 in patients with early Alzheimer's disease (AD), on track for 2024 Participant baseline characteristics in pivotal INFRONT-3 Phase 3 trial ...