cGAMP binds to Stimulator of Interferon Genes (STING) which triggers phosphorylation of IRF3 via TBK1. IRF3 can then go to the nucleus to trigger transcription of inflammatory genes. This pathway ...

More information: Bo Lv et al, A TBK1-independent primordial function of STING in lysosomal biogenesis, Molecular Cell (2024) ...