Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

How cells changing their shape or moving orchestrate their cytoskeleton? Cells and tissues are not static structures, but during development they change their size and shape and migrate. Plasticity of ...

The group found the shape maximizes light absorption and angular coverage when compared to flat-structured cells, suggesting the structure would be beneficial for applications requiring flexible ...

How do Cancer Cells Adopt Different Shapes During Metastasis? The migration of cells is an essential event during organism development and for many functions in the adult organism. For example immune ...

We are focused on understanding how gene regulation occurs through novel mechanisms of mRNA translation. Specifically, we study how non-canonical translation pathways shape cell growth and ...

Now, an international team of mathematicians has discovered a new class of shapes capable of tiling with a minimal amount of ...

When that occurs, cell signaling becomes hyperactive and indiscriminate. Zhang explains, "Different microdomains control ...

Each component in the animal cell has a particular function. Animal cells often have an irregular shape. The four key components of most animal cells are: Nucleus - this contains the genetic ...