Fibrosis is a leading cause of death and disability ... leading to severe anemia, an enlarged spleen, clotting disorders, and hemolytic complications that can lead to death within several years ...

with data that show how survival benefits are biologically linked to changes in the spleen, reduction in fibrosis, or other responses. Treatment of myeloproliferative neoplasms (MPNs) has ...

Inrebic showed superior spleen volume reduction and symptom response compared to BAT in myelofibrosis patients previously treated with Jakafi. The FREEDOM2 trial involved 134 patients treated with ...

enlarged liver and spleen, and mental deficiencies. Because of the progressive nature of MPS I, a child might not exhibit noticeable symptoms until one to three years of age or even later ...

They have an enlarged spleen. They may even have some degree ... 42 had stable or improved fibrosis, including eight patients who had resolution bone marrow fibrosis after 48 weeks.