Roberts in 1958. Subsequent studies by James Watson, Francis Crick, and others revealed the central role of ribosomes in protein synthesis, laying the foundation for our current understanding of these ...

HHMI scientists and their colleagues discover a new mechanism of protein synthesis. Ribosomes are the cell’s molecular machines, responsible for translating genetic information in messenger RNA into ...

The large subunit rRNA, in particular, is responsible for the peptidyl transferase reaction, which catalyzes the formation of peptide bonds between amino acids during protein synthesis. This discovery ...

Differences in the ribosomal densities of the two daughters produced by a mother Escherichia coli could explain the asymmetry of aging and growth rate in previously reported such daughter pairs.

“Over 40 percent of the clinically useful antibiotics target protein synthesis, mostly by paralyzing the ribosome,” she notes. But her interactions with pharmaceutical companies about new ...

We showed that non-AUG translation is strikingly resistant to multiple protein synthesis inhibitors, including cycloheximide. We find that these inhibitors slow elongating ribosomes, thereby inducing ...

This valuable study reveals extensive binding of eukaryotic translation initiation factor 3 (eIF3) to the 3' untranslated regions (UTRs) of efficiently translated mRNAs in human pluripotent stem ...