Ribonucleosides such as 5-azacytidine or zebularine are reduced at the diphosphate level by ribonucleotide reductase for incorporation (not shown). Once in DNA, the fraudulent bases form covalent ...

Hydroxyurea is a ribonucleotide reductase inhibitor. This drug is well tolerated and effectively controls leukocytosis in the majority of stable-phase patients. Toxicity is primarily hematologic ...