whereas class 2b peptides imply all encoded protein sequences. In combination, class 1a, 1b and 2a peptides can thus be informative in identifying and distinguishing different splice isoforms.

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

“The field has been hampered by antibodies that recognize the wrong (or multiple) protein isoforms and antibodies that don’t work well in particular applications,” says Andrew ...

Alternative splicing is crucial for eukaryotic gene expression and influences protein function and regulation ... discussing ...

while leaving other PI3K isoforms largely untouched. Over about 20 years, the Genentech team gradually developed molecules ...

In a report released today, Bradley Canino from Stifel Nicolaus maintained a Buy rating on Black Diamond Therapeutics (BDTX – Research ...