With it he showed it was possible to reverse the protein-folding problem by designing a protein shape and then predicting the ...

The new focus on the protein folding problem, which includes a discussion on the kinetic consequences of rapid pre-equilibria and the relevance of transition state theory in light of advances in ...

Although fast kinetics demonstrated that protein folding is not a simple two-state reaction, these experiments did not solve the problem of isolating and characterizing the structures of folding ...

Protein folding has been an ongoing problem for researchers since 1972. Christian Anfinsen speculated in his Nobel Prize acceptance speech in that year that the three-dimensional structure of a ...

(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) Although the Nobel Prizes in physics and chemistry are awarded separately, there ...

The "protein-folding problem" is important because most biological processes — such as how insulin controls blood-sugar levels or how antibodies fight coronaviruses — are driven by proteins.

In 2024, the Nobel Prize in physics was awarded to John Hopfield and Geoffrey Hinton for their foundational work in ...

But now, AI systems are poised to dramatically accelerate this painstaking process. For decades, scientists puzzled over the ...

A new article examines the convergence of physics, chemistry, and AI, highlighted by recent Nobel Prizes. It traces the historical development of neural networks, emphasizing the role of ...

Grain size is positively correlated with grain ... The endoplasmic reticulum (ER) is a major organelle responsible for protein folding and trafficking. Protein folding stress in the ER can lead to ...