Taken together, these studies have firmly established RAF, PI3K and RAL signaling as key downstream effectors of KRAS that promote lung tumorigenesis. While other direct RAS effectors have been ...

Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window HOUSTON -- Two-thirds of patients with PI3K-mutant brain metastases responded to the maximum tolerated dose (MTD ...

Subsequent activation of PI3K, Ras and PLC-γ results in pericyte migration, survival and proliferation. Collectively, induction of these three signaling cascades results in pericyte recruitment ...

is a clinical-stage biopharmaceutical company advancing a next generation pipeline of novel small molecule therapeutics targeting RAS and PI3K malignancies. Initially formed as a subsidiary of ...

Pharmacodynamic studies confirmed inhibition of both PLK1 and PI3K activity and pronounced apoptosis in the combination-treated tumors. The findings support that targeting PLK1 and PI3Kα with ...